December 22, 2025, Shenzhen — Professor Bu Guojun led his research team to visit Shenzhen Cell Valley, where they engaged in in-depth exchanges with the valley's scientific research and industrialization teams regarding frontier research and novel cellular therapy strategies for neurodegenerative diseases, including Alzheimer's disease (AD).Professor Bu Guojun currently serves as the Head of the Division of Life Science at the Hong Kong University of Science and Technology (HKUST). He previously held the position of Chair of the Department of Neuroscience at the Mayo Clinic Alix School of Medicine in the United States and is an internationally renowned scholar in the field of Alzheimer's disease research.
Representing Shenzhen Cell Valley were Professor Shi Yuanyuan, Chairman of Shenzhen Cell Valley Group; Dr. Zhao Lijun, Head of R&D; and Dr. Fu Yuchen, Senior R&D Scientist, among others. Both parties conducted systematic and in-depth discussions focusing on the pathogenesis of neurodegenerative diseases, selection of key targets, technical routes for cell and gene therapies, as well as future models for cooperation in scientific research and clinical translation.
Focusing on Alzheimer's Disease: From Mechanistic Breakthroughs to New Ideas in Cellular Therapy During the seminar, both parties focused primarily on Alzheimer's disease, a global medical challenge.Professor Bu Guojun's team has long been dedicated to researching the mechanisms of APOE receptors and lipid metabolism in neurodegenerative diseases. They have accumulated systematic research findings regarding early pathological progression, key regulatory pathways, and potential intervention targets of the disease, providing a solid theoretical foundation for the precision treatment of Alzheimer's disease. Building on this, both parties explored feasible pathways for deeply integrating Shenzhen Cell Valley's technologies in cell and gene therapy vectors, GMP-grade cell preparation capabilities, and clinical translation experience with the frontier basic research of Professor Bu's team. Key areas of focus include: • Target validation and cellular therapy strategy design oriented by disease mechanisms; • The application potential of novel gene delivery and cell engineering technologies in nervous system diseases; • The construction of systematic translation pathways from laboratory research to clinical studies. Both parties agreed that this collaborative model of "Basic Research + Engineering Platform + Clinical Translation" holds promise for exploring groundbreaking new therapeutic ideas for Alzheimer's disease.
Joining Hands to Build an Innovation Highland for Neurodegenerative Diseases in the Greater Bay Area This exchange not only deepened the consensus between Shenzhen and Hong Kong in the field of cellular therapy for neurodegenerative diseases but also injected new momentum into the collaborative innovation of biomedicine in the Guangdong-Hong Kong-Macao Greater Bay Area.Professor Shi Yuanyuan, Chairman of Shenzhen Cell Valley, stated: "The international frontier achievements of Professor Bu Guojun's team in the field of Alzheimer's disease basic research are highly complementary to Shenzhen Cell Valley's mature industrialization and clinical translation platforms. Cooperation between both parties will help bridge the critical chain from mechanism research and technology development to clinical application, accelerating the process by which innovative outcomes truly benefit patients."
In the future, relying on the unique advantages of Shenzhen and Hong Kong in scientific research, industry, policy, and international resources, both parties will continue to advance joint research and translation exploration in the field of cell and gene therapy. This effort aims to help build a biomedical innovation ecosystem with international influence and contribute the "Shenzhen-Hong Kong Solution" to addressing major health challenges brought about by an aging society.
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